/* Themes Wordpress Theme URI: https://wordpress.org/themes/ Author: the WordPress team Author URI: https://wordpress.org/ Description: Wordpress brings your site to life with header video and immersive featured images. With a focus on business sites, it features multiple sections on the front page as well as widgets, navigation and social menus, a logo, and more. Personalize its asymmetrical grid with a custom color scheme and showcase your multimedia content with post formats. Our default theme for 2017 works great in many languages, for any abilities, and on any device. Version: 2 License: GNU General Public License v2 or later License URI: http://www.gnu.org/licenses/gpl-2.0.html Text Domain: wordpress.org Tags: one-column, two-columns, right-sidebar, flexible-header, accessibility-ready, custom-colors, custom-header, custom-menu, custom-logo, editor-style, featured-images, footer-widgets, post-formats, rtl-language-support, sticky-post, theme-options, threaded-comments, translation-ready This theme, like WordPress, is licensed under the GPL. Use it to make something cool, have fun, and share what you've learned with others. */ /*-------------------------------------------------------------- >>> TABLE OF CONTENTS: ---------------------------------------------------------------- 1.0 Normalize 2.0 Accessibility 3.0 Alignments 4.0 Clearings 5.0 Typography 6.0 Forms 7.0 Formatting 8.0 Lists 9.0 Tables 10.0 Links 11.0 Featured Image Hover 12.0 Navigation 13.0 Layout 13.1 Header 13.2 Front Page 13.3 Regular Content 13.4 Posts 13.5 Pages 13.6 Footer 14.0 Comments 15.0 Widgets 16.0 Media 16.1 Galleries 17.0 Customizer 18.0 SVGs Fallbacks 19.0 Media Queries 20.0 Print --------------------------------------------------------------*/ /*-------------------------------------------------------------- 1.0 Normalize Styles based on Normalize v5.0.0 @link https://github.com/necolas/normalize.css ---------------------------------------------------------------- html { font-family: sans-serif; line-height: 1.15; -ms-text-size-adjust: 100%; -webkit-text-size-adjust: 100%; } body { margin: 0; } article, aside, footer, header, nav, section { display: block; } h1 { font-size: 2em; margin: 0.67em 0; } figcaption, figure, main { display: block; } figure { margin: 1em 0; } hr { -webkit-box-sizing: content-box; -moz-box-sizing: content-box; box-sizing: content-box; height: 0; overflow: visible; } pre { font-family: monospace, monospace; font-size: 1em; } a { background-color: transparent; -webkit-text-decoration-skip: objects; } a:active, a:hover { outline-width: 0; } abbr[title] { border-bottom: 1px #767676 dotted; text-decoration: none; } b, strong { font-weight: inherit; } b, strong { font-weight: 700; } code, kbd, samp { font-family: monospace, monospace; font-size: 1em; } dfn { font-style: italic; } mark { background-color: #eee; color: #222; } small { font-size: 80%; } sub, sup { font-size: 75%; line-height: 0; position: relative; vertical-align: baseline; } sub { bottom: -0.25em; } sup { top: -0.5em; } audio, video { display: inline-block; } audio:not([controls]) { display: none; height: 0; } img { border-style: none; } svg:not(:root) { overflow: hidden; } button, input, optgroup, select, textarea { font-family: sans-serif; font-size: 100%; line-height: 1.15; margin: 0; } button, input { overflow: visible; } button, select { text-transform: none; } button, html [type="button"], [type="reset"], [type="submit"] { -webkit-appearance: button; } button::-moz-focus-inner, [type="button"]::-moz-focus-inner, [type="reset"]::-moz-focus-inner, [type="submit"]::-moz-focus-inner { border-style: none; padding: 0; } button:-moz-focusring, [type="button"]:-moz-focusring, [type="reset"]:-moz-focusring, [type="submit"]:-moz-focusring { outline: 1px dotted ButtonText; } fieldset { border: 1px solid #bbb; margin: 0 2px; padding: 0.35em 0.625em 0.75em; } legend { -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; color: inherit; display: table; max-width: 100%; padding: 0; white-space: normal; } progress { display: inline-block; vertical-align: baseline; } textarea { overflow: auto; } [type="checkbox"], [type="radio"] { -webkit-box-sizing: border-box; -moz-box-sizing: border-box; box-sizing: border-box; padding: 0; } [type="number"]::-webkit-inner-spin-button, [type="number"]::-webkit-outer-spin-button { height: auto; } [type="search"] { -webkit-appearance: textfield; outline-offset: -2px; } [type="search"]::-webkit-search-cancel-button, [type="search"]::-webkit-search-decoration { -webkit-appearance: none; } ::-webkit-file-upload-button { -webkit-appearance: button; font: inherit; } details, menu { display: block; } summary { display: list-item; } canvas { display: inline-block; } template { display: none; } [hidden] { display: none; } --------------------------------------------------------------*/ Viagra, Cialis, Levitra, Kamagra – ED Medications - Archive - Asthma
Header image

Furthermore, treatment of asthma not only can improve airflow limitations and reduce symptoms but also can modify underlying AHR. These observations have given insight into the factors and mechanisms that affect AHR and, in particular, the role and contribution, if any, of airway inflammation in the variety of processes that determine and possibly direct AHR.

To more fully appreciate the role of inflammation in AHR, it is helpful to identify the components that likely make up AHR, review studies that have used either therapeutic interventions or provocative models to modify AHR, and, from these observations, attempt to gain a more comprehensive view of the complexity of processes, including inflammation, that ultimately determine AHR.

What Are the Components

In studying, discussing, and understanding the components that comprise AHR, it is helpful, and possibly informative, to divide the factors that contribute to AHR into two categories: persistent and variable (Fig 2). Under this concept, which may be an oversimplification of this feature of asthma, the persistent aspects of AHR have been largely attributed to structural changes in the airway, which can include subendothelial thickening, subbasement membrane thickening, smooth muscle hypertrophy, matrix deposition, and altered vascular components (Fig 3). These structural changes are often part of the histopathology found in asthma, particularly in those patients with more severe or longstanding disease; these structural changes alter the architecture of the airways to make them thicker, less compliant, and more narrowed, all features associated with a greater degree of constriction and closure when stimulated by contractile substances. The other component of AHR, the variable aspect, is believed to relate to inflammatory events in the airway, which are variable and influenced by numerous environmental events (ie, allergens, respiratory infections, and treatment). In arbitrarily dividing the components of AHR into these two principal components, it is understood that these processes are interrelated and likely interdependent.